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KMID : 0367420050480111239
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Journal of Korean Pediatric Society
2005 Volume.48 No. 11 p.1239 ~ p.1243
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Serum Ferritin as a Risk Factor in Type 2 Diabetes Mellitus
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Kim Jung-Hyun
Kim Ho-Seong
Kim Duk-Hee
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Abstract
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Purpose: Iron accumulation interferes with hepatic insulin extraction and affects insulin synthesis and secretion. The purpose of this study is to investigate the correlation between serum ferritin and type 2 diabetes mellitus.
Methods: We compared the serum ferritin level among 18 patients in an impaired glucose tolerance (IGT) group, 36 in a type 1 diabetes group, eight in a type 2 diabetes group and 29 in a healthy control group. The correlation between serum ferritin levels and sex, body mass indices(BMI), blood pressure(BP), serum fasting sugar level and serum fasting insulin level were also analyzed.
Results: The mean log ferritin were 1.33+/-0.32(healthy control group), 1.63+/-0.19(IGT group) and 1.90+/-0.30(type 2 diabetes group). In the IGT group, log ferritin was higher than in the healthy control group(P=0.001). The log ferritin of the type 2 diabetes group was higher than that of the healthy control group(P=0.001). Comparing log ferritin to other factors, log ferritin had a significant positive correlation with body mass indices(P<0.001), systolic blood pressure(P=0.001), and fasting glucose(P= 0.001), fasting insulin(P=0.002).
Conclusion: Compared to the normal healthy group, serum ferritin concentrations were significantly higher in the IGT group and the type 2 diabetes group. The elevation of serum ferritin concentration may be a risk factor of type 2 diabetes mellitus.
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KEYWORD
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Serum ferritin, Type 2 diabetes mellitus, Insulin resistance syndrome
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